Recombination fraction

\(r=\text{”Probability of recombination in a gametic pool”}\) \(r=\frac{\text{nº of crossovers}}{\text{nº of base pairs}}\) \(0\leq r \leq 0.5\)

Morgan, M, is the length of a segment that produces on average 1 crossover \(E[\text{nº of crossovers in 1M}]=1 \)

It varies between species and chromosome regions. Under the assumption that r is constant across the chromosome we can use it to map genes in a chromosome and measure the chromosome size.

IMPORTANT: The recombination fraction is not additive: \(r_{AC} \neq r_{AB}+r_{BC}\). There is no lineal relation between \(r_{AC}\) and \(x_{AC}\). To translate from Morgan to base pairs we use map functions: Haldane Map Function and Kosambi Map Function.

In practice we estimate the recombination fraction and use a map function to convert it into base pairs.

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